Vitamin B12 Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin B12, including details on cyanocobalamin, benefits, supplements, deficiency, side-effects, sources.

Methyl transfer reactivity of five-coordinate CH3CoIIIPc.

Galezowski W

Department of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland. wlodgal@amu.edu.pl

CH3CoIIIPc (Pc = dianion of phthalocyanine) has been characterized by equilibrium studies of its trans axial ligation and cyclic voltammetry as a relatively "electron poor" model of methylcobalamin, which in noncoordinating solvents persists as a five-coordinate complex. Axial base (N-donors, PBu3, SCN-, weakly binding O-donors) inhibition of methyl transfer from CH3CoIIIPc shows that the reaction proceeds via the reactive five-coordinate species, even in coordinating solvents. The virtual inactivity of six-coordinate CH3CoIIIPc(L) complexes provides a reference point for important biological processes.

Published 28 February 2005 in Inorg Chem, 44(5): 1530-46.
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